1. All the work is being done at the knee joint, whereas in squats or legpress you use your hips. So they do put more stress on the knees than squats.
2. They are an isolation exercise, and they do not fully recruit the rectus femoris. The vastus medialis does the majority of the work.
3. They're only real purpose, be it bodybuilding or athletic training, is for rehab.
Personally, I haven't done one in over 3 years, and I have superior quad development compared to most people my size and training experience.
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