Then I pose this question: How can you perform 35 working sets in a session and expect to recover correctly for another in 48 hours when every set is taken to failure and your CNS is drained?
We are running a course straight into a debate consisting of anecdotal jargon, a versus of "I do this and this happens so this must be true", a debate I personally don't have the time, ambition, nor patience to take part in, since there is no distinct line to draw a winner.
That said, I'd like to discus some basic efferent nerve physiology, specifically those in the CNS and how it applies to over training, overload and hypertrophy.
First, a quick, basic background on how a muscle cell fibers. Most nuerons (nerve cells) carry a -70mv charge with a threshold for excitation at an average of -55mv. When a message is sent, sodium rushes into the nerve cell increasing the charge and causing the cell to fire upon the next cell. This occurs along the nerve path until it reaches the muscle, where the final motor nueron fires, and if the "firing" is strong enough, the muscle contracts.
Everytime a nerve fires, its threshold for excitation is increased, and a stronger stimulus (from the previous nerve) must be applied for it to fire. It takes time and energy for the neuron to pump out the sodium to return to its orriginal charge.
Now consider this along your entire CNS, from spinal column to motor nerves, triggering millions of motor units (groups of muscle fibers) to contract when performing a back squat.
Now imagine performing that back squat to true failure, how frequent the nuerons must fire (and with what intensity) on the final set to "squeeze" out that final rep, how high their threshold for excitation has increased and how much of a stimuli must be applied in order to keep the muscle fibers firing. How would you feel if i told you to run 10x100 yard sprints at 100% intensity with a 1:1 work to rest ratio!
Now consider the pumping period and the energy needed to pump the sodium out, the potassium back in, and regain a charge of -70mv in each cell. Apply this over 3-5 training sessions per week, taking compound movements to failure and you can see how the potential for CNS over training drastically increases.
On top of this, the microtrauma caused by negatives, forced reps, drops sets, etc. causes the release of inflamatory cyotkines into your body which circulates and attaches to receptors on your CNS impeding neural recovery. Generally this microtrauma is relative to the volume of negatives performed (this is why eccentric movements are mainly responsible for DOMS).
There's even more to this, like excess build up potassium ions at neuromuscular junction and excess release of calcium inside the muscle cell causing it to be less sensitive to nerve impulses (think drinking to intoxication for a few weeks straight then trying to get drunk off what you were able to before that binge).
Br
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