There are different physiological responses to varying work to rest ratio's.
Hypertrophy is achieved in two levels.
One, your myofillaments increase in number and size.
Two, satellite cells "spill" their contents into the muscle fiber, increasing the size of sarcoplasm and intrasarcoplasmic organelles. They also contribute another nucleus to control a portion of the sarcoplasm and organelles.
Different w:r's will account for the different changes associated with hypertrophy.
Br
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