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Originally Posted by LoudHoward Hmmm, that's very interesting. I can't exactly 'feel' glutamine working. Would you mind posting some links to the info? You have really gotten me thinking on this one... |
Sure. I can point to is study after study showing it doesnt help.
The purpose was to determine if glutamine supplementation would prevent a loss of lean mass in athletes during a 12-day weight reduction program. It was hypothesized that supplementation would spare lean body mass. Subjects (n=18) exercised and dieted to create a 4186kJ·day-1 energy deficit and a 8372 kJ·day-1 energy deficit on days 1-5, days 6-12, respectively. The glutamine (GLN) group (n=9) ingested 0.35 g·kg-1 body mass of glutamine while a placebo was administered to the remaining subjects. Body mass (BM), lean body mass (LBM) and fat mass (FM), were measured at days 0, 6, and 12. GLN and placebo groups both lost significant amounts of BM, LBM and FM. There were no significant differences between groups. The findings indicate little benefit for retention of lean mass with supplementation of glutamine during a short-term weight reduction program.
Glutamine supplementation did not benefit athletes during short-term
weight reduction
Kevin, J. Finn, Robin Lund and Mona Rosene-Treadwell
http://www20.uludag.edu.tr/%7Ehakan...n4/7/v2n4-7.htm
Lok7y (Avant Labs rep):
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Glutamine is a waste of money--really unnecessary IMHO. Replace with some form of creatine (either monohydrate or ethyl ester [CEE]).
Patrick Arnold (ErgoPharm owner and one of the most respected chemists in the field):
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fooling around with glutamine is a waste of time, unless you are sick or very weakened
str8flexed (B.S. in biochemistry):
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you know the glutamine you lose from the muscle during a workout that everyone freaks out about? all these companies talk about? That's not even stored glutamine! It's made as you workout by taking the ammonia group from BCAAs and through a series of transfers transfering the amine group to another donar to form glutamine. All glutamine is doing is acting as an ammonia carrier since free ammonia is toxic. All that glutamine you "lose" during training wouldn't have ever even existed if it wasn't for the fact you were training.
1)Results of tracer studies indicate that skeletal muscle contributes to approximately 70% of overall glutamine production in healthy adults; the contribution of de novo synthesis being estimated at approximately 60%. Direct and specific measurements of glutamine in intact muscle protein are 50% lower than assumed previously (G1).
2)Most amino acids are precursors for alanine and glutamine synthesis in skeletal muscle. Cysteine, leucine, valine, methionine, isoleucine, tyrosine, lysine, and phenylalanine increase the rate of glutamine synthesis. The progressive decline in alanine and glutamine synthesis noted on prolonged incubation is prevented by the addition of amino acids to the incubation medium (G2)
Glutamine does not increase protein synthesis:
-Intravenous
infusion of amino acids increases the fractional rate of mixed muscle protein synthesis, but addition of glutamine to the amino acid mixture does not further stimulate muscle protein synthesis rate in healthy young men and women (G6).
-Short intravenous infusion of glutamine does not acutely stimulate duodenal protein synthesis in well-nourished, growing dogs (G8).
Glutamine prevents protein degradation but not more effectively than carbs:
-0,9 g/kg glutamine during resistance training has no significant effect on muscle performance, body composition or muscle protein degradation compared to 0,9 g/kg maltodextrin (G9).
-Glutamine preserves protein synthesis in Caco-2 cells submitted to "luminal fasting", but higher glutamine doses did not enhance protein synthesis beyond control fed values. And glucose supplementation restored FSR as effi-ciently as glutamine (G10).
Carbhohydrate or BCAA supplementation prevents decrease in glutamine levels during exercise:
-Carbohydrate supplementation affects positively the immune response of cyclists by avoiding or minimizing changes in plasma glutamine concentration (G11).
-Following an exercise bout, a decrease in plasma glutamine concentration can be observed, which is completely abolished by BCAA supplementation (G12).
-BCAA supplementation during a triathlon completely prevents the decrease in plasma glutamine (G13).
(G1)
http://www.ncbi.nlm.nih.gov/entrez/q...016&query_hl=1
(G2)
http://www.ncbi.nlm.nih.gov/entrez/q...059&query_hl=1
(G6)
http://www.ncbi.nlm.nih.gov/entrez/q...116&query_hl=1
(G7)
http://www.ncbi.nlm.nih.gov/entrez/q...808&query_hl=1
(G8)
http://www.ncbi.nlm.nih.gov/entrez/q...312&query_hl=1
(G9) [url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=118224 73&dopt=Abstract/url]
(G10)
http://ajpgi.physiology.org/cgi/content/full/285/1/G128
(G11)
http://www.ncbi.nlm.nih.gov/entrez/q...341&query_hl=1
(G12)
http://www.ncbi.nlm.nih.gov/entrez/q...939&query_hl=1
(G13)
http://www.ncbi.nlm.nih.gov/entrez/q...884&query_hl=1
Soure : Big'r
IMO, save your cash. And there you have it. There is not much more to be said. :)
