I posted this as a reply to another thread, but figured more folks might read it if I made a new thread...
Below is a post and a study as well as part of a PM conversation I had on another board with a member named DatBTrue. He is an independant researcher and really quite intelligent and well read. I haven't started this protocol yet as I'm saving it for bulking...but thought maybe members might like a read.
Quote:
I understand not wanting to use exogenously administered insulin. Does this mean you would lose out on insulin's contribution to GH induced anabolism?
No...you can achieve what would amount to a couple iu of Hum-R by using glucose & leucine. The two work synergistically to spike insulin.
About 3.5 grams of Leucine was sufficient to double the insulin response to 25grams of glucose. See below:
Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose, Dionysia Kalogeropoulou, Metabolism Clinical and Experimental 57 (2008) 1747–1752
Thereafter, they received 25 g glucose or 1 mmol/kg lean body mass leucine or 1 mmol/kg lean body mass leucine plus 25 g glucose in random order. Serum leucine, glucose, insulin, glucagon, and alpha-amino nitrogen concentrations were measured at various times during a 2.5-hour period after ingestion of the test meal. The amount of leucine provided was equivalent to that present in a high-protein meal, that is, that approximately present in a 350-g steak. After leucine ingestion, the leucine concentration increased 7-fold; and the alpha-amino nitrogen concentration increased by 16%. Ingested leucine did not affect the serum glucose concentration. When leucine was ingested with glucose, it reduced the 2.5-hour glucose area response by 50%. Leucine, when ingested alone, increased the serum insulin area response modestly. However, it increased the insulin area response to glucose by an additional 66%; that is, it almost doubled the response. Ingested leucine stimulated an increase in glucagon. Ingested glucose decreased it. When ingested together, the net effect was essentially no change in glucagon area. In summary, leucine at a dose equivalent to that present in a high protein meal, had little effect on serum glucose or insulin concentrations but did increase the glucagon concentration. When leucine was ingested with glucose, it attenuated the serum glucose response and strongly stimulated additional insulin secretion. Leucine also attenuated the decrease in glucagon expected when glucose alone is ingested. The data suggest that a rise in glucose concentration is necessary for leucine to stimulate significant insulin secretion. This in turn reduces the glucose response to ingested glucose. |
So, in summary:
PWO - Hi-GI carbs + Leucine
20 minutes later -eat protein, carbs, even a little fat
Slin-Sane buy 2 get 1 FREE!!!!!
