It is clear that leucine increases protein synthesis by increasing the activity of mTOR & the phosphorylation of eIF4G.
Leucine has a far greater stimulatory effect on protein synthesis than any other amino acid and it has been shown that protein synthesis increases similarly in response to a relatively small dose of leucine compared to a whole food meal.
It has also been demonstrated that adding leucine to a protein rich meal further increases the rate of skeletal muscle protein synthesis.
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