Background on HGH and terminology
HGH and hGH refer to "human growth hormone." The reader may be curious as to why only this hormone is still often referred to as "human" when the term could obviously be appended to every hormone in the article Hormone. After three-letter abbreviations of amino acids were found so useful in the 1950s, endocrinologists in the 1950s tended to favor 3 letter abbreviations even for two-word hormones. At that time, most of the hormones available for administration, especially the proteins, were derived from animals. Most were similar, if not identical, to human hormones in structure and effectiveness.
However, animal growth hormones were relatively ineffective in humans because of structural differences. Human growth hormone purified from human pituitaries was a rare commodity used therapeutically between 1963 and 1984. The abbreviation hGH distinguished it from animal growth hormones in medical reports. When synthetic, human-sequence GH made by recombinant DNA technology replaced use of cadaver hGH in the mid-1980s (when it was associated with the development of Creutzfeldt-Jakob Disease and withdrawn from all use), the term HGH no longer made sense, and endocrinologists largely stopped using the term for synthetic growth hormone. The abbreviation rGH can be used to refer to synthetic human-sequence growth hormone made by recombinant DNA technology, but to most endocrinologists, human growth hormone is simply "GH," whether measured in the blood or given by injection.
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