Quote:
Originally Posted by harmankardon1  is liquidex useful for pct??? could i use it instead of clomid? or to be used with it ? how efficent is it |
Got this off a research website, they use a scale to grade it like in elemantary school A being the best and F the worst:
LIQUIDEX
""From the research I've done, this seems to be the best ancillary compound around for use on a cycle. First off, 1mg per day of this stuff (J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 ) was shown to decrease estrogen by about 50% and increase testosterone levels by 58%. That’s a level of estrogen suppression I’m very comfortable with on virtually any cycle. Interestingly, that same study showed that those results were had with .5mgs/day as well. So, since you can elevate testosterone, lower estrogen (but not excessively), and keep healthy joints and lipids, and do this at a half mg per day, I give this my highest rating for an ancillary product to use on a cycle…""
Grade: A
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Clomid
Clomid is a drug given to women as a fertility aid, which acts by binding to the estrogen receptor and thereby blocking estrogen from doing the same in some tissues. It can bind to breast tissue, and prevent estrogen from binding there to cause gynocomastia -although it is not nearly as effective as nolvadex. It can also stimulate the HPTA (Hypothalamic-Pituitary-Testicular-Axis), and stimulates LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone). LH and FSH stimulate the release of testosterone. Unfortunately, Clomid does this only weakly, and there are much better ancillary products on the market. It works, but I think Nolvadex is much better.
Final Grade: C-
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Nolvadex
Nolvadex is a Selective Estrogen Receptor Modulator. This means that it acts on the Estrogen receptor (called the "ER"). Now, this also means that it acts as an estrogen in some tissues which acts as an anti-estrogen in some tissues.
The estrogen receptor's ligand binding domain is just of a number of amino acid sequences "folded" into a series of helixes, which have the ability to change conformation. Different stimuli (such as Nolvadex) are well documented to have the ability to change the conformation of a very important helix (helix 12, for those keeping score at home).
When estradiol binds the ER, this particular helix takes on a conformation that allows DNA transcription to mRNA, and estrogenic effects are then expressed in the body. When Nolvadex (Tamoxifen) binds to it, the antagonist changes the shape of this helix in such a way that it now folds (or bends) in such a way to prevent proper binding of estrogen, and subsequent transcription of DNA to mRNA.
Sadly, if you take progesteronic steroids and use nolvadex, you may be at an increased risk for progesteronic sides, as nolvadex may increase progesterone receptors (Gynecol Oncol. 1999 Mar;72(3):331-6). So besides competing with estrogen at the receptor, these drugs both increase serum test levels, and both drugs may also alter blood lipid profiles. With regards to Clomid and Nolvadex, I’ve found some research that indicates that 20mgs of tamoxifen is equal to 150mgs of clomid for purposes of testosterone elevation, FSH and LH, but tamoxifen did not decrease the LH response to LHRH (Fertil Steril. 1978 Mar;29(3):320-7). Interestingly, Nolvadex can even be used in small doses just as effectively as larger doses, when it comes to sperm indices and spermatogenesis. (“Effect of lower versus higher doses of tamoxifen on pituitary-gonadal function and sperm indices in oligozoospermic men”. Dony JM, Smals AG, Rolland R, Fauser BC, Thomas CM.) So in this case, we can actually use much lower doses than the egregiously recommended 40-60mgs/day. 5mgs a day seems to be as effective as 20, with regards to basal or LHRH stimulated gonadotropin and testosterone response or the E2/T ratio (Ibid).
So that makes Nolvadex great for preventing gyno, and superb for Post Cycle Therapy even at lower dosages, but not my favorite Ancillary product during a cycle, unless I need to help my lipid profile or just prevent gyno. I give nolvadex a …
Final Grade: B-
