why take it with meal? real simple, for the same reason you should take any medicine that is toxic with food just like antibiotics. If you take it raw it will give you lotīs of problems including nausea, stomach pain it can even give you (fistulas) internal sores. With food you will minimize those effects. An acidic environment is needed for the digestion that takes place in the stomach.When you are eating your body produces stomach juices (enzymes) that help your body digest the food and those are a must when taking in toxic
substances, cause they will stop the medicines from destroying the intestinal walls made of good bacterias.
The digestive system is made of microbacterias that live in harmony and are responsible . The inner wall of the small intestine is covered with millions of microscopic, finger-like projections called villi. The villi are the vehicles through which nutrients can be absorbed into the body.
+++hope it makes some type of sense+++