Yes, over at another board (where I am most well known) I posted some literature on why peoples LR3 IGF-1 cycles aren't able to push past the 3 1/2 to 4 week mark as far as results are concerned. I will be posting the exact article in this forum soon so you will be able to read the specifics of it but basically it has to do with the receptor downregulation and recovery time. The recovery takes in excess of 24 hours and with these massive dosages of LR3 IGF-1 (remember your body makes a very very small amount of IGF-1Ea, the natural variant, and it is still 3-10x less potent than LR3 IGF) and also the extended half life of LR3 IGF-1 it doesn't give your body enough time.
I advocated E3D+ injections and some people tried it and really liked it. One guy did 3x per week and the other did E4D. The person who did E4D injections said it was an interesting feeling because he still had that extreme hunger that he had when he was doing ED injections. It was originally thought that 2x daily injections would work well since it would keep plasma levels high, as LR3 IGF-1's half life is <24 hours long, and this is true, however, I reversed my statement a while back and said single injections are better since blood glucose levels were still at low levels even after a single injection and it allows for better recovery of receptors, which is mediated through tyrosine kinase (MAPK and PI3K pathways).
I would say that 20-60mcg E4D would probably be the way to go personally. I think 40mcg would be a great starting point, but as little as 20 will definitely still keep blood glucose levels down. There isn't any research out there on LR3 IGF-1 in humans (that is published or available anyways) and the pharmaceutical companies are keeping their research under raps for now, so really all we can do is try things out based on science and see how they work :).
Keep me updated.
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