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Phenadrine
Advanced Lipolytic Stimulant
Intense Workout Potentiator
Based on a carefully crafted unique matrix of proven and effective agents, coupled with advanced and highly innovative compounds at potent pharmaceutical-grade doses, Phenadrine effortlessly takes versatility and synergy to completely new levels. With a two-in-one punch, Phenadrine fuses advanced lipolytic stimulation and intense workout potentiation like no other supplement. A standard setter, Phenadrine will deliver results right from the first dose. Every time! No tolerance build up! No hit-and-miss! Phenadrine was engineered to work; to catapult your performance to a new league. Get ready for the most intense workout and fat-melting experience of your life!
Phenadrine delivers:
· Unparalleled pre-workout and fat-incinerating results
· The most intense workout of your life. Every time!
· Intense focus, concentration, mental clarity and alertness
· Previously unknown levels of jitter-free energy with no crashes
· Dramatic boost in energy and physical performance
· Advanced multiple pathways for rapid and effective fat-loss
· Increased vascularity and pump
· Enhanced protein synthesis and elevated testosterone production
· Modulation of estrogen and cortisol levels
· Improved sexual performance
Serving size: 1 cap/60caps per bottle
750mg per (1) capsule
N-Acetyl-Tyrosine
Icariin
Caffeine
1,3 Dimethylamylamine
N-Methyl-Beta-Methylphenylethylamine HCL
Methyl-synephrine
Engineered to unleash previously unknown levels of synergy, Phenadrine’s unsurpassed actives, including the novel and single most effective designer fat-loss compound, N-Methyl-Beta-Methylphenylethylamine HCL, collectively yield a new standard-setting advanced pharmaceutical-grade lipolytic stimulant and intense workout initiator. The matrix consists of:
N-Acetyl L-Tyrosine
N-Acetyl-Tyrosine (NAT) is an acetylated form of the essential amino acid, L-Tyrosine. NAT is more water soluble, and is therefore, a rapidly absorbed and more bio-available form than pure L-Tyrosine. L-Tyrosine modulates the synthesis of cortisol and thyroid hormones, as well as that of neurotransmitter catecholamines such norepinephrine (noradrenaline), epinephrine (adrenaline) and dopamine, that are depleted by stress. So, NAT supplementation reduces the impact of stress and fatigue and elevates cognitive performance. The neurotransmitter-stimulation action of NAT further synchronizes with similar synergistic action from 1,3-Dimetylamylamine and caffeine (caffeine stimulates release of catecholamines and NAT modulates their synthesis), leading to enhanced thermogenesis and lipolysis. Furthermore, by modulating thyroid hormones, NAT supports optimised base metabolic rate, promotes protein synthesis and glucose metabolism, enhances lipid metabolism by increasing adipose tissue sensitivity to hormones that modulate fat breakdown. As is well known, even a slight increase in active thyroid-hormone levels can produce a dramatic improvement in metabolism, energy levels, and mental attitude. Besides, NAT’s cortisol-modulating impact supports reduced fatigue, better recovery, and reduced adipose storage.
Icariin
An epimedium flavonoid and testosterone mimetic, icariin is a natural anabolic that possesses a variety of unique pharmacological actions in the body. It plays an important role in modulating nitric oxide levels by inhibiting an important enzyme, phosphodiesterase type 5 (PDE-5), that breaks down another enzyme, 3’,5’-cyclic Guanosine Monophosphate (cGMP). cGMP signals the smooth muscles to relax, enhancing blood flow. So, PDE-5 inhibition prolongs the action of cGMP, making possible the flooding of skeletal muscle tissue with nutrient-rich blood and oxygen, leading to improved muscle contraction, intense pump and vascularity, as well as promoting an environment conducive to anabolism. This PDE-5 inhibition is also the mechanism behind icariin’s dramatic improvement in sexual function in users. Furthermore, icariin, like testosterone, competes with glucocorticoids for receptor-site binding. By blocking glucocorticoids from binding to cortisol receptor sites, icariin inhibits cortisol action. This leads to an increase in the testosterone:cortisol ratio, triggering enhanced protein synthesis and anabolism. Furthermore, icariin produces a boost in cAMP levels, demonstrates estrogen-modulation properties, stimulates prolactin inhibition (via its action on dopamine receptors, thereby triggering an increased testosterone production), and promotes increased production of luteinizing hormone. Net, the cAMP elevation, selective cGMP inhibition, glucocorticoid antagonism, and estrogen modulation, all combine to improve the testosterone:cortisol and testosterone:estrogen ratios. Furthermore, via its function as an important acetylcholinesterase inhibitor, icariin boosts levels of the neurotransmitter, acetylcholine. This inhibition drives movement and promotes stronger muscle contractions, and a dense skeletal muscle structure.
Caffeine
Caffeine, a methylxanthine and popular stimulant, not only possesses lipolytic and appetite suppressant properties, but also helps to enhance endurance and extent the effect of other stimulants. As a CNS stimulant, caffeine works as an adenosine A1 and A2A receptor antagonist. This is significant because adenosine modulates the action of neurotransmitters such as dopamine, norepinephrine, and acetylcholine. Adenosine blocks the activity of excitatory neurotransmitters, creating a tatigue and a feeling of apathy. By antagonizing adenosine, caffeine stimulates nerve-cell activity, creating enhanced alertness and clarity. Furthermore, caffeine inhibits the enzyme, phosphodiesterase (PDE), that breaks down cAMP. This PDE inhibition leads to sustained cAMP activity and boosting norepinephrine, thereby up-regulating thermogenesis and lipolysis. These pathways ensure caffeine traces a synergistic action with 1,3-Dimethylamylamine and other agents in Phenedrine, creating an optimally fuelled fat-burning furnace in your body.
Something else: Two enzymes, arginase and nitric oxide synthase compete against each other for the nitric-oxide metabolic pathway. The enzyme arginase converts arginine to ornithine and urea. Nitric oxide synthase converts arginine to nitric oxide, the potent vasodilator. A higher expression of the arginase enzyme leads to higher ornithine production, but less nitric oxide production. Now enters caffeine (methylxanthine caffeine). Caffeine inhibits arginase activity. It does this by inhibiting the so-called adenosine receptors, leading to higher levels of free adenosine. Now, adenosine, adenine, inosine, and uric acid, are known to be competitive arginase inhibitors. Furthermore, caffeine and caffeine-related compounds, also produce arginase inhibition by raising norepinephrine and cAMP. The caffeine-triggered arginase inhibition produces an elevated expression of the nitric-oxide synthase enzyme. This means even more nitric oxide is made available, leading to stronger vasodilation (and pump).
1,3-Dimethylamylamine
Also known as Geranamine, 1,3-Dimethylamylamine, a derivative of geranium oil, possesses a pharmacological activity similar to that of epinephrine (adrenaline), the body’s endogenous chemical messenger. As a potent fat burner, 1,3-Dimethylamylamine activates an enzyme, adenylate cyclase, that elevates cyclic adenosine monophosphate (cAMP) in cells, triggering fat metabolism. This is also one of the chemical pathways employed by ephedrine to potentiate fat burning. Furthermore, 1,3-Dimethylamylamine demonstrates potent central-nervous system (CNS) stimulation, leading to enhanced energy and physical performance, heightened focus and concentration, enabling the user to achieve a previously unknown intensity during training. The user will experience a significant elevation in energy levels without the usual crash common with many other stimulants.
1,3-Dimethylamylamine is often combined with caffeine to further consolidate the heightened energy, intense concentration and focus, as well as euphoric feelings.
N-Methyl-Beta-Methylphenylethylamine HCL
This is a truly unique and novel compound, and one of compounds that sets Phenadrine apart from competition. Chances are you are familiar with the pharmacological pathways of Beta-Phenylethylamine (PEA). You may also be familiar with N-Methyl-Beta-Phenylethylamine HCL. Yet, do not confuse N-Methyl-Beta-Phenylethylamine HCL with our much more potent agent, N-Methyl-Beta-Methylphenylethylamine HCL with several methyl groups that render it super stable and remorselessly effective. This novel agent works! That simple!
But why are PEA and its molecular derivatives even important for fat loss?
A remarkable compound, even in its pure form, Beta-Phenylethylamine (PEA), a catecholamine precursor and nutrient found in chocolate, is known to be a very clean stimulant with the remarkable ability to achieve central-nervous-system stimulation without producing nervousness or the jittery feeling associated with other stimulants. Like norepinephrine, the body’s most potent endogenous fat-burning hormone, PEA acts on alpha-receptors in the brain, triggering the release of the “feel-good” hormone, dopamine (3,4-dihydroxy-phenethylamine) in neural cells. PEA is also responsible for chocolate’s effect on mood, sense of satiety, reduced food cravings, mild euphoria, as well as increased metabolic rate (by modulating thyroid function). Also known as a neuromodulator, PEA promotes mental alertness, focus and concentration. By regulating catecholamines such as epinephrine (adrenaline) and norepinephrine (noradrenaline) that act on hormone-sensitive lipase, the rate-limiting enzyme in the mobilization of fatty tissue from storage cites, PEA elevates the metabolic rate, ultimately leading to increased fat burning. Unfortunately, PEA is rapidly metabolised in the body by type B monoamine oxidase and has a limited ability to cross the blood-brain barrier, thus preventing it from unleashing its full effects. The challenge was to obtain a form of PEA with a type B monoamine-oxidase inhibitor property. N-Methyl-Beta-Phenylethylamine HCL is an N-Methyl derivative of Beta-Phenylethylamine. This methylated form of PEA is dramatically more potent than pure PEA, and takes PEA’s CNS stimulation and fat-burning several notches higher. While we could have used this compound, we decided to aim still higher. Now enters N-Methyl-Beta-Methylphenylethylamine HCL. This novel and carefully engineered unique agent represents the most potent form of PEA ever developed. It is not an N-Methyl derivative of N-Methyl-Beta-Phenylethylamine HCL, rather an N-Methyl derivative of methylated Beta-Phenylethylamine HCL! It is like “double methylation”! Such compounds do not come more potent than this! Technically speaking, we astronomically boosted the pharmacokinetic value of PEA! This “double methylated” form unites the finest properties of PEA such as easily crossing the blood-brain barrier to elevate feelings of euphoria, intensifying fat-burning due to optimised beta-receptor agonism while demonstrating unprecedented stability to B monoamine oxidation, implying a longer-lasting and significantly more intensive overall action. Our N-Methyl-Beta-Methylphenylethylamine HCL is by far the most potent designer fat-loss agent ever developed, and you would not find it in many of fat-loss products around. It elevates the potency of our synergistic blend to never-before-seen levels! You will be convinced!
Methyl-Synephrine HCL
Do not mistake this compound for pure synephrine! It is light years away, in terms of superiority. If synephrine worked for you, Methyl-Synephrine HCL will blow your mind! First, back to the basics. What is synephrine? Obtained from the citrus tree known as Citrus aurantium or Bitter Orange, synephrine is an active alkaloid with structural similarities to epinephrine and norepinephrine. Synephrine’s claimed thermogenic, lipolytic, and appetite suppression effects are derived from its alpha-adrenergic properties that provoke the activation of beta-3 receptors. The claim that synephrine’s beta-3-receptor binding triggers lipolysis at very high dosages appeared to based on Carpene et al (1999). Subsequent studies, e.g., Larsen et al (2002) and Bent et al (2004), however, demonstrated that beta-3-receptor agonists appeared to have dramatically less lipolytic action in human fat cells, compared to animal fat cells.
The picture, however, appears to change significantly with the use of a recently developed unique form of synephrine referred to as Methyl Synephrine. Using the methylated form of synephrine (derived by substituting or attaching a methyl group to different molecules) dramatically alters its pharmacological pathway, and appears to make the compound significantly more effective than pure synephrine. Methyl synephrine is an adrenergic amine that has unique and amplified pharmacological effects by acting, not only as a beta-3 receptor agonist, but also as an alpha-1 adrenergic agonist. This difference is significant, because pure synephrine is postulated to act as a beta-3-receptor agonist only. This means methyl synephrine works by significantly up-regulating the metabolic rate and enhancing fat metabolism and thermogenesis, while only mildly stimulating the central nervous system without adversely impacting blood pressure and heart function, unlike beta-2 receptor agonists such as ephedrine that trigger anxiety and irregular heartbeat. As a beta-3-receptor agonist, methyl synephrine up-regulates the action of epinephrine and norepinephrine (the most potent endogenous fat-burning agent around) within adipose tissue, leading to significant lipolysis. So methyl synephrine not only up-regulates fat breakdown (as a beta-3 receptor agonist), but also profoundly enhances the burning of released body fat for energy (as an alpha-1 agonist). Double punch!
As you can see, Phenadrine is no regular “kitchen-sink” formula. Rather, it represents a new standard in “double-punch” products that effectively combine intense-workout potentiating compounds with advanced lipolytic and thermogenic agents to deliver the performance you are looking for, and that we are known for. Our unique matrix of selected agents is delivered in pharmaceutical-grade purity and in potent per-dose-amounts that work every time. If you are looking for an effective double-punch product beyond the reach of competition, your search stops at Phenadrine! Advanced Lipolytic Stimulant. Intense Workout Potentiator
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