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Gastrointestinal Distress: Gastrointestinal distress is the secondly most common side effect reported. Incidences of stomach cramps, nausea, flatulence, and diarrhea are more commonly reported during the loading phase when greater amounts of creatine are consumed each day. These side effects are principally due to the presence of large quantities of undissolved creatine particles residing within the intestinal compartment. Remember, creatine has the propensity to draw water into the body compartment where it is found (see above). If the body compartment in question is the large intestine, then excessive water absorption may lead to diarrhea and intestinal cramps. These side effects can often be largely circumvented by making sure that creatine is completely dissolved in at least 16 ounces of water (or juice) and never consuming more than the recommended dosing amount (see Question #7).
To circumvent incidences of gastrointestinal distress, micronized and effervescent forms of creatine have been developed. These forms of creatine are more easily absorbed into the blood stream and, hence, have less of a tendency to collect within the intestinal compartment. Downstream the increased solubility of these products this will help evade gastrointestinal complications. You can find out more about the different forms of creatine by reading my Creatine Products Review. Learn the theory behind the formulations of the most popular creatine products on the market. After reading this review, anyone will be able to determine which additives are truly enhancing the properties of a given creatine product, or are merely added to inflate the price and to give a false sense of innovation. This review is normally included as a bonus to those purchasing Creatine: A practical guide. However, you can download an abbreviated version of the Creatine Products Review for free.
The presence of additives or contaminants may also be a source of gastrointestinal discomfort. These days, it seems as if every creatine manufacturer is trying to distinguish their particular product from the rest of the crowd. Each day new marketing twists are appearing with the main objective of making their particular products appear superior to all the rest. As a result more and more extraneous agents are being added to the growing list of creatine products (see above). People who experience gastrointestinal discomfort from creatine may merely be sensitive to these additives and not to the creatine per se. If your particular brand of creatine gives you an upset stomach, switch to a source of pure creatine monohydrate. It's thus important that you purchase your creatine from a reputable creatine provider.
Flatulence: The large amounts of sugars often consumed with creatine may lead to flatulence, complicate gastric emptying and lead to cramps (see Question #4). Certain sugars, particularly when consumed in large quantities, may pass undigested through the small intestine and ultimately collect (nearly intact) in the large intestine. Here, intestinal bacteria decompose the sugar, releasing gas. If sufficiently large amounts of gas are produced to exert pressure within the intestinal compartment, then cramps may ensue. Flatulence, obviously, is the expelling of the gas produced by the bacteria. | 
