[Lion Force]

My understanding is that the brainstem releases gnrh which releases LH and FSH which govern the leydig cells conversion of cholesterol into testosterone. Growth hormone is released from the brainstem and in the liver releases insulin like growth factor one. I do not know the function of IFG-2. Of these hormones what are the logistics of how they govern protein synthesis. I release that protein consumed - protein burned when carb depleted = protein aviable for body structure. I am digging into my actual protein synthesis.

[flytrapcan]

Ummm, ok

Seriously where's Layne for this one.

[Freak]

The hypothalmus is responsible for all of the releasing hormones for the anterior pituitary. GH, LH, TSH, FSH, ACTH, and Prolactin are hormones of the anterior pituitary.

By not having carbs high enough yeah you are digging into your protein synthesis. Carbs are protein sparing - meaning they are used for glucose so amino acids can be used for growth and repair.

IGF-2 just promotes growth during gestation.

Hope this helps!

[Lion Force]

Ok, so in between meals when I have burned off my liver glycogen I begin to draw glycogen from my muscles to fuel my liver which thereby fuels my central nervous system. When I have burned off a significant amount of glycogen, to what point I do not know I begin to burn incoming protein. That incomeing protein would otherwise replace the protein leaving the body as structure.

So IGF-2 is for gestation. That leaves me with testosterone and growth hormone/ IGF-1. I am thinking that these three hormones contorol the rate that the body turns out new muscle and bone and that preserving protein with plenty of carbs there is more protein aviable to build with.

[Freak]

That's the general idea but there are more hormones in play than 3. You have leptin, ghrelin, insulin, then you can get into neurochemicals CRH/PYY and it gets pretty advanced. It's not just a few hormones its a complex web.

[Lion Force]

Leptin, ghrelin, insulin, then you can get into neurochemicals CRH/PYY, could the brainstem cut back on gonadotropin releasing hormone and growth hormone if Leptin or ghrelin feedback are weak? If so this must be why some inject exogenous hormones into their bodies.

Insulin Like Growth factor-1, I understand makes the body turn out muscle and bone at a higher rate. Does growth hormone do this too or is it a precurser to IGF-1?

[Freak]

Originally Posted by Lion Force

Leptin, ghrelin, insulin, then you can get into neurochemicals CRH/PYY, could the brainstem cut back on gonadotropin releasing hormone and growth hormone if Leptin or ghrelin feedback are weak? If so this must be why some inject exogenous hormones into their bodies.

Insulin Like Growth factor-1, I understand makes the body turn out muscle and bone at a higher rate. Does growth hormone do this too or is it a precurser to IGF-1?

Please make the distinction between feedback and low levels of the circulating hormone, or are you talking about receptor insensitivity. They are all similar but all different.

If leptin levels are normal then growth hormone and testosterone will be normal but when leptin is low, PYY and CRH increase, which crashes testosterone and gh. t3 is lowered so your metabolic rate is decreased and your appetite is suppressed.

What hormones are you referring to when you say, "If so this must be why some inject exogenous hormones into their bodies."

Leptin injections aren't reasonably available. Check out Parlodel (Bromocriptine) if you are interested in keeping leptin levels normal during a cut.

Yes gh is responsible for that.

[Thomas_Rivera]

Freak isn't it the opposite with leptin? Doesn't appetite go up and metabolic rate go down?

[Freak]

Nope. You are probably thinking of ghrelin.

[Thomas_Rivera]

Kidney International - Low leptin gene expression and hyperleptinemia in chronic renal failure

"since leptin is thought to be an inhibitor of appetite"

And a few other places suggest that high leptin levels decrease appetite.

[Thomas_Rivera]

Or am I mixing it up that ghrelin actively increases hunger while leptin levels are low and high levels of leptin levels decrease hunger when fat stores are high and leptin levels are up?

[Freak]

Leptin decreases appetite and increases metabolic rate. On a diet, leptin drops and the reverse happens, appetite is increased and metabolic rate decreases. I partially mis-spoke on my first post.

I said with low leptin levels your appetite would be suppressed but no, your appetite levels increase with low leptin levels.

[Freak]

In the short term leptin is effected by energy balance and in the long term bf levels effect leptin. You are spot on in post #11.

[Thomas_Rivera]

Mistakes happen to the best of us

[Freak]

Thanks for pointing it out. Now go take Parlodel (Bromocriptine) and make a log :)

[Thomas_Rivera]

Your going to be taking Bromocriptine? I'd like to see how it goes, I started to read Lyle McDonalds book on it, it sends a false signal to the brain that causes metabolism to remain normal even while dieting, correct?

[Lion Force]

By feedback I mean the intensity of ghleren and leptin reaching the brain. When the intensity of these is lowered, such as in a diet, hormones that control protein synthesis would be aviable in lower amounts. Is this a reason to put exogenous hormones into your body? Eating, sleeping, training and possibly the psychological impact the levels of homones produced by the body. With exogenous hormones one could have elevated hormone levels under the worst of conditions. Of course you are still limited by the amount of protein aviable, so you would have to eat enough calories from protein and carbohydrates or protein alone to have enough protein not to be burned.

As for leptin I recognize the purpose of exogenous leptin as topping off leptin would keep other hormones elevated.

[Freak]

Yes that would be a reason to take aas.

exogenous leptin isn't available at a price that is anywhere reasonable and our goal isn't to increase it beyond normal levels it is to return it to normal levels on a cut.


That's exactly right Thomas. I can email you my notes. Jake and I read the whole thing and imo he doesn't get to the main point fast enough. My notes are 4 pages in a word document. I've thought about taking it but doubt I ever will idk.

[Thomas_Rivera]

Sure i'd like the notes.

[Freak]

pm me your email