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Protein synthesis
Old 09-03-2008, 12:25 PM   #1
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My understanding is that the brainstem releases gnrh which releases LH and FSH which govern the leydig cells conversion of cholesterol into testosterone. Growth hormone is released from the brainstem and in the liver releases insulin like growth factor one. I do not know the function of IFG-2. Of these hormones what are the logistics of how they govern protein synthesis. I release that protein consumed - protein burned when carb depleted = protein aviable for body structure. I am digging into my actual protein synthesis.
 
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Old 09-03-2008, 08:51 PM   #2
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Ummm, ok

Seriously where's Layne for this one.
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Old 09-03-2008, 11:45 PM   #3
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The hypothalmus is responsible for all of the releasing hormones for the anterior pituitary. GH, LH, TSH, FSH, ACTH, and Prolactin are hormones of the anterior pituitary.

By not having carbs high enough yeah you are digging into your protein synthesis. Carbs are protein sparing - meaning they are used for glucose so amino acids can be used for growth and repair.

IGF-2 just promotes growth during gestation.

Hope this helps!
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Old 09-04-2008, 11:41 AM   #4
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Ok, so in between meals when I have burned off my liver glycogen I begin to draw glycogen from my muscles to fuel my liver which thereby fuels my central nervous system. When I have burned off a significant amount of glycogen, to what point I do not know I begin to burn incoming protein. That incomeing protein would otherwise replace the protein leaving the body as structure.

So IGF-2 is for gestation. That leaves me with testosterone and growth hormone/ IGF-1. I am thinking that these three hormones contorol the rate that the body turns out new muscle and bone and that preserving protein with plenty of carbs there is more protein aviable to build with.
 
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Old 09-04-2008, 01:31 PM   #5
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That's the general idea but there are more hormones in play than 3. You have leptin, ghrelin, insulin, then you can get into neurochemicals CRH/PYY and it gets pretty advanced. It's not just a few hormones its a complex web.
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Old 09-04-2008, 05:37 PM   #6
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Leptin, ghrelin, insulin, then you can get into neurochemicals CRH/PYY, could the brainstem cut back on gonadotropin releasing hormone and growth hormone if Leptin or ghrelin feedback are weak? If so this must be why some inject exogenous hormones into their bodies.

Insulin Like Growth factor-1, I understand makes the body turn out muscle and bone at a higher rate. Does growth hormone do this too or is it a precurser to IGF-1?
 
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Old 09-04-2008, 07:21 PM   #7
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Quote:
Originally Posted by Lion Force View Post
Leptin, ghrelin, insulin, then you can get into neurochemicals CRH/PYY, could the brainstem cut back on gonadotropin releasing hormone and growth hormone if Leptin or ghrelin feedback are weak? If so this must be why some inject exogenous hormones into their bodies.

Insulin Like Growth factor-1, I understand makes the body turn out muscle and bone at a higher rate. Does growth hormone do this too or is it a precurser to IGF-1?
Please make the distinction between feedback and low levels of the circulating hormone, or are you talking about receptor insensitivity. They are all similar but all different.

If leptin levels are normal then growth hormone and testosterone will be normal but when leptin is low, PYY and CRH increase, which crashes testosterone and gh. t3 is lowered so your metabolic rate is decreased and your appetite is suppressed.

What hormones are you referring to when you say, "If so this must be why some inject exogenous hormones into their bodies."

Leptin injections aren't reasonably available. Check out Parlodel (Bromocriptine) if you are interested in keeping leptin levels normal during a cut.

Yes gh is responsible for that.
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Old 09-04-2008, 10:33 PM   #8
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Freak isn't it the opposite with leptin? Doesn't appetite go up and metabolic rate go down?
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Old 09-04-2008, 11:16 PM   #9
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Nope. You are probably thinking of ghrelin.
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Old 09-04-2008, 11:32 PM   #10
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Kidney International - Low leptin gene expression and hyperleptinemia in chronic renal failure

"since leptin is thought to be an inhibitor of appetite"

And a few other places suggest that high leptin levels decrease appetite.
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Old 09-04-2008, 11:34 PM   #11
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Or am I mixing it up that ghrelin actively increases hunger while leptin levels are low and high levels of leptin levels decrease hunger when fat stores are high and leptin levels are up?
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Old 09-04-2008, 11:43 PM   #12
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