[borobulker]

The Six Pack Stack Sack: What it is


USPlabs Six-Pack Stack @ Orbit Nutrition

A dynamic and open dialogue used to facilitate the growing number of Six Pack Stack-specific questions. All of the representatives, including myself, will consistently update this thread with any new suggestions or strategies to best maximize these two products! Alternatively, we will also pay keen attention to this particular thread, as we did with our Quick Questions Thread.

Essentially, this is an FAQ tool, of sorts; a more evolving and dynamic way to ensure products are properly maximized, rather than a stiff, rigid, and unchanging user guide. While the basics featured on product pamphlets and websites will be found here, they will not be presented in a cut-and-paste type format; they will be altered and expounded upon specific to each consumer's unique needs.

Further, it will exist as a real-time guide for individual's wishing to track their progress, and express their feelings on this specific stack of USPlabs progress. Almost like a mini community within a community.

We want this to be a community involvement. I plan on starting the stack as part of my recomp in the next couple of weeks. I plan to post my diet up for you guys to critique and get your opinion on some cardio plans...

Post up guys... Who is running the stack? When did you start?

[borobulker]

The Stack Itself:The Six Pack Stack

As in other parts of nature, the human body is regulated by the storage and expenditure of energy – this process is at the heart of each one of the body’s metabolic processes, from growth, to vision, to digestion, to excrement.

As an evolutionary response, the human body became a finely tuned complex of mechanisms meant to opportunistically metabolize energy – that is, store energy for future use, or during times of adequate intake to facilitate growth (anabolic response); or, to produce energy from stored nutrients in times of inadequate intake (catabolism).

Sounds like a sweet deal, huh? Your cells demand energy, or reject it, and your body metabolizes nutrients accordingly! However, a certain problem has arisen, leading to issues of adipogenesis – the modern diet!

Quite simply, the evolution of the human body’s energy metabolism pathways were born of necessity: our ancestors scarcely ate high levels of ligands, choosing instead animal proteins and lipids, while simultaneously encountering long bouts of famine. In this respect, our storage pathways, especially in terms of adipocytes (fat cells) were necessary, as whatever nutrients were encountered needed to be fully utilized. However, these once ‘life-saving’ energy mechanisms are now ‘diet-killing’ frustrations!

With a fitness diet, ample with caloric energy for cells, these mechanisms now lead to the hypertrophy of fat cells, via the binding to blood lipids, GLUT4 upregulation leading to adipocyte glucose storage, and deregulation of energy expenditure messengers. The solution: The Six Pack Stack!

Both Anabolic Pump and ReCreate are veritable titans of energy homeostasis – regulating all of the body’s major metabolic pathways to assist in achieving the most favorable tissue composition possible!

Here is how:

Anabolic Pump: As much as Anabolic Pump is a supplement meant to achieve glucosehomeostasis, and thought of as such, its success is due to its ability to mitigate energy expenditure pathways within the body. Specifically, Berberine's direct stimulation of AMPk, a master regulatory 'switch', so to speak, of intracellular energy metabolism. In normal (i.e., non-supplemented) states of exercise, AMPk plays a vital role in maintaining cellular energy, via both a glycolytic and oxidative role - that is, initially inducing glycolysis to provide energy for cellular reactions, and oxidizing fatty acids in longer bouts. This occurs due to an increase in the extracellular AMP:ATP ratio. As ATP increases, the body is in extreme demand for cellular energy during exercise. At this point, AMPk upregulates energy producing mechanisms (translocation of GLUT4, FFA oxidation) and downregulates energy consuming pathways (protein and fatty acid synthesis).

This glycolytic and oxidative manners of energy exchange is why AP provides tangible body composition changes - delivering intracellular messages, at the genetic level (via PPAR family) for adipocytes to oxidize and expend energy, while signaling for myocytes to do the complete opposite. Amazingly, the regulation of energy metabolism is not exclusive to Berberine, but is accomplished by Lagerstroemia Speciosa as well; constituents within LS have been shown to selectively regulate proteins responsible for the induction of GLUT4 in myocytes, while denying the same process in adipocytes. Further, the PPAR family of lipid-binding proteins mentioned previously in relation to Berberine are mitigated by LS as well! Simply put, Anabolic Pump genetically alters the mechanisms our body uses to maintain energy homeostasis – effectively upregulating energy expenditure –very selectively – in order to produce body composition changes!

ReCreate: The amount of energy expenditure pathways that ReCreate modulates is quite astounding! In respects to the AMPk discussion had previously, ReCreate increases, very prominently, levels of cAMP and ATP – key messengers of extracellular energy metabolism; in terms of nutrient synthesizing, ReCreate vastly increases levels of T3, the active Thyroid Hormone responsible for the metabolism of lipids, proteins, and carbohydrates; in terms of energy production and stress response, ReCreate inhibits the production of Cortisol at the enzymatic level, ensuring that catabolic response Is attenuated in skeletal muscle, thereby further sensitizing muscle cells to Insulin, ensuring nutrient metabolism occurs efficiently, and that the body remains in positive nitrogen balance; and finally, in a lipid-specific respect, ReCreate even mitigates HSL (hormone sensitive lipase), an enzyme responsible for the induction of lipolysis dependent on the hormone’s which ReCreate is already modulating!

Plainly, the combination of Anabolic Pump and ReCreate alters your body’s natural energy pathways at the genetic level! Preventing adipogenesis, and promoting lipolysis, while simultaneously remaining in positive nitrogen balance were once thought impossible. Now, with these pioneering supplements, not only is it possible, but readily attainable! Just like your brand-new six pack!!

[T.O]

Thanks boro yeah this stack has been on fire. People love it. :)

[mikeh40+]

looks like one heck of a stack boro!

[borobulker]

Originally Posted by Teamorbit

Thanks boro yeah this stack has been on fire. People love it. :)

Myself included! I would love to see more guys over here in the Dungeon posting up their results!!!

[borobulker]

Originally Posted by mikeh40+

looks like one heck of a stack boro!

You know it my friend... Unreal results...

Thanks!

[GRAVESY079]

I have been looking for something new. I will have to come back to this come decision time.

[borobulker]

Originally Posted by GRAVESY079

I have been looking for something new. I will have to come back to this come decision time.

Awesome... Let me know if you need any additional info!

[angryJawa]

I read a ridiculously hard to believe article in a Vitamin Shoppe free magazine about Recreate. It was an talking about a customer returning it because it was working too well and they were losing too much weight too fast. If anyone actually has this problem please let me know. I could use something that works too well.

[T.O]

hahaha thats does sound retarted but the product does work very well I can say that much. lol

[borobulker]

Originally Posted by angryJawa

I read a ridiculously hard to believe article in a Vitamin Shoppe free magazine about Recreate. It was an talking about a customer returning it because it was working too well and they were losing too much weight too fast. If anyone actually has this problem please let me know. I could use something that works too well.

We would not back the article if it were not true. You can call the store manager at the location and ask for yourself. He would not put himself (and Vitamin Shoppe) on the line for a lie. He actually approached us with the info, not the other way around.

If you would like more information on Recreate, please let me know.

[borobulker]

Originally Posted by T.O

hahaha thats does sound retarted but the product does work very well I can say that much. lol

Retarded to me is buying a fat-burner because a top IFBB pro endorses it...

[T.O]

True but I meant sounds retarted that that the guy would bring it back. Same thing would be for me to bring Prime back because I couldnt fit in my shirts any more due to all the new muscle :)

[borobulker]

Originally Posted by T.O

True but I meant sounds retarted that that the guy would bring it back. Same thing would be for me to bring Prime back because I couldnt fit in my shirts any more due to all the new muscle :)

Just wait...

[angryJawa]

Originally Posted by borobulker

We would not back the article if it were not true. You can call the store manager at the location and ask for yourself. He would not put himself (and Vitamin Shoppe) on the line for a lie. He actually approached us with the info, not the other way around.

If you would like more information on Recreate, please let me know.

Good point. Please send me more info. I'm actually looking for at Fat Burning products to pick up in the next week.

[borobulker]

Originally Posted by angryJawa

Good point. Please send me more info. I'm actually looking for at Fat Burning products to pick up in the next week.

If you need any more info, please let me know!


USPlabs Recreate

Ingredient Profile:

750mg (proprietary blend) Carralluma Fimbrata, Coffea Arabica L., Olea Europaea, Caffeine, Forslean (extract of Colleus Forskholli), (2-(4-(beta-D-Glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one) extracted from Microtea Debilis.

Method of Action:

Forskolin (Forslean):

An adenlyate cyclase activator, which in turn increases intracellular levels of cAMP (cyclic adenosine monophosphate), which eventually works to stimulate lipolysis in adipose cells. Beta 2-adrenergic agonists such as ephedrine and clenbuterol actually work by increasing cAMP as well. Unfortunately, because they work at a receptor, their effectiveness can decrease with continued use as the body down-regulates the number of receptors available. Forskolin bypasses the receptor and directly activates adenylate cyclase, obviating the need for “cycling”, and foregoing potential risks associated with beta-2 Agonists. Another potential benefit is that accumulation of cAMP in skeletal muscle may provide an anti-catabolic/anabolic effect as well [1]. A study which evaluated body composition found that when they gave forskolin to men (without having them change their normal habits), they were able to reduce body fat percentage by 4.14%. In addition, they were able to lose 4.52 kg (9.9 lb) of fat mass and gained 3.71 kg (8.2 lb) of lean body mass (muscle tissue), over a 12 week period [2]. It also slightly increased free testosterone in men, but this would not likely occur in women.

Caffeine:

If there were one potential downfall of forskolin, it would be that the body still has a few mechanisms to reduce cAMP levels, either via modulation of adenylate cyclase activity or degradation of cAMP itself. Caffeine has the potential to work against such mechanisms to increase the effects of forskolin.

Olea europaea:

An extract (performed in a very particular way) of olive leaf, was shown to possess potent thyroid stimulatory properties when it increased T3 levels by nearly 300% as compared to the control group in a study using an animal model [3]. Here is the best part. Unlike many plant extracts which only have an effect in animal models when the dose employed is the equivalent to a human consuming their entire bodyweight of the substance per day, this actually works at a very low dose. Additionally, the thyroid stimulating effects with this plant are dose-dependent.

Coffea Arabica L:

Again, a very precise extract of this substance has been shown to inhibit the enzyme 11-B-hydroxysteroid dehydrogenase type 1, both selectively and very potently [4]. In addition, it was shown to do so in muscle and adipose cells. Why is this good? 11beta-HSD1 is an enzyme responsible for converting the very weak glucocorticoid, cortisone, into the much more powerful, cortisol. We all know that excess cortisol can hamper your progress in the gym, and with the stress of living in our modern world, it’s certain that few people don’t have elevated cortisol levels. Unfortunately, this particular enzyme works against what we all as athletes and bodybuilders would like and works to increase cortisol levels. In addition, another sad bit of news is that activity of this enzyme only seems to increase as we get older [5].

By inhibiting 11beta-HSD1, it is thought that it could be used to treat obesity (reduce body fat) and improve insulin sensitivity. Additionally, a beneficial effect upon muscle mass would be expected [6].

Caralluma fimbriata:

A very specific extract of this plant was shown to reduce waist size by almost one and a quarter inches in only 8 weeks, while decreasing appetite by 20% as compared to placebo [7]. In addition, those taking the active ingredient reduced consumption of sweets, refined sugars, cholesterol and saturated fats by the conclusion of the study as compared to placebo. At the same time, consumption of fruits, vegetables and fish didn’t change. In other words, it nearly “made” them follow a healthy diet and make better food choices, while also causing them to eat less. The group taking the caralluma lost 1.5 kg (3.3 lb) of fat mass as well, over the course of the study. It has been used for centuries by tribal populations that wished to suppress their appetite. It also has a well established safety record and had shown no serious adverse effects. As far as how it works, it is thought that steroidal glycosides present in the plant may increase ATP in the hypothalamus, potentially “tricking” it into thinking that energy or food intake is sufficient so there is no need to increase appetite [7,8].

(2-(4-(beta-D-Glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one) extracted from Microtea Debilis) Cactus Alkaloids:

A compound found in a certain cactus plant, has a structural similarity to norepinephrine. It has both alpha and beta-adrenergic activity [9]. Additionally, it directly stimulates postsynaptic receptors while enhancing the physiological effects of norepinephrine via increasing synthesis of it and inhibiting its’ reabsorption. The end result is a stimulant effect similar to ephedrine, without the “all over the place” behavior. In fact, it produces a great deal of focus.

Literature:
[1] Navegantes LC, Resano NM, Migliorini RH, et al. Catecholamines inhibit Ca(2+)-dependent proteolysis in rat skeletal muscle through beta(2)-adrenoceptors and cAMP. Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E449-54

[2] Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 2005 Aug;13(8):1335-43.

[3] Al-Qarawi AA, Al-Damegh MA, ElMougy SA. Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Phytother Res. 2002 May;16(3):286-7

[4] Atanasov AG, Dzyakanchuk AA, Schweizer RA, et al. Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee? FEBS Lett. 2006 Jul 24;580(17):4081-5.

[5] Wiegand S, Richardt A, Remer T, et al. Reduced 11{beta}-hydroxysteroid dehydrogenase type 1 activity in obese boys. Eur J Endocrinol. 2007 Sep;157(3):319-324

[6] Walker BR. Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning. Proc Nutr Soc. 2007 Feb;66(1):1-8

[7] Kuriyan R, Raj T, Srinivas SK, et al. Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women. Appetite. 2007 May;48(3):338-44.

[8] MacLean DB, Luo LG. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside. Brain Res. 2004 Sep 10;1020(1-2):1-11

[9] Sato PT, Neal JM, Brady LR, et al. Cactus alkaloids. XVI. Isolation and identification of alkaloids in Coryphantha ramillosa. J Pharm Sci. 1973 Mar;62(3):411-4

[10] Girotti C, Ginet M, Demarne FC, et al. Lipolytic activity of cirsimarin extracted from Microtea debilis. Planta Med. 2005 Dec;71(12):1170-2