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A must read on nitrix oxide and NO products
Old 05-15-2007, 08:53 PM   #1
heydespo5269
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Don't waste your money on the supplement industry's newest hype product. It's a waste of money and unsafe. Here's a good article I found which has valid sources. If you want a good pump in gym have a balance of good carbs like brown rice and oats and train hard.

"Nitric oxide supplements are the hottest thing on the market. Athletes are buying them in droves without knowing exactly what is happening in the body. Supplement companies claim to educate their consumers with pamphlets and informational websites, but these only offer an incomplete story of what is actually happening. Manufacturers state that nitric oxide supplements, via the compound arginine alpha-ketoglutarate, gives the athlete added energy, mental focus, workout intensity, perpetual pump and muscle growth. Upon closer investigation, these effects are largely exaggerated and in some cases completely fallacious. While arginine is involved in the regulation of growth hormone release, the supplemental dosages that would stimulate a noticeable effect are astronomical. Arginine is also a substrate for nitric oxide; an effect that is enhanced when combined with alpha-ketoglutarate. Nitric oxide is released by the walls of the blood vessels that cause a decrease in the resistance and an increase in blood flow to the skeletal muscles. Arginine may also stimulate the release of epinephrine from the adrenal gland. These two effects are mostly beneficial to endurance athletes, not strength athletes like the manufacturers suggest. Grasemann et al. (2005) determined that participants receiving as little as 200 mg of L-arginine showed a significant increase in nitric oxide formation, as well as significant increases in plasma L-arginine and sputum L-arginine. This indicates that L-arginine supplementation does indeed induce nitric oxide formation. Rytlewski et al. (2005) found that three weeks of L-arginine supplementation lead to significant drops in systolic blood pressure, diastolic blood pressure, and mean arteriole pressure while elevating urinary excretion of NOx (nitrates) and mean plasma levels of l-citrulline. However, plasma L-arginine levels were not effected even with 300 mg of supplementation. Thusfar it has been established that L-arginine supplementation does indeed stimulate nitric oxide synthesis. Now it must be addressed whether or not this is beneficial to athletes.

Paddon-Jones et al. (2004) found that nitric oxide supplementation does not provide an ergogenic effect to healthy individuals. Miguez et al. (2004) found that 4 weeks of L-arginine supplementation increased serum triglyceride levels and significantly increased levels of low-density lipoprotein (LD) cholesterol. This is obviously cause for concern and needs to be further investigated. Evans et al. (2004) sought to find the optimal dosage of L-arginine to elicit the greatest effect on nitric oxide synthesis. Manufacturers recommend upwards of 6000-10000 mg/day but many athletes report taking even higher dosages as much as 35000 mg/day, nearly six times the recommended intake. Evans (2004) found that half the participants supplementing with 20000 mg/day reported serious adverse side effects from L-arginine supplementation and over half of the participants reported severe side effects when taking more than 20000 mg/day. A significant portion of individuals supplementing with 9000 mg/day reported adverse effects, and over the duration of the supplementation period, no participants experienced any sort of weight gain. Chu et al. (2004) found that L-arginine supplementation impaired pulmonary endothelium-dependent relaxation of vascular tissue. This may lead to potentially dangerous vascular spasms and cardiovascular abnormalities.

It has been found that L-arginine keto-gluterate supplementation stimulates rapid vasidilation in a non-discriminatory fashion. Significant vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, significant drop in both systolic and diastolic blood pressure. During exercise, it is imperative that diastolic blood pressure remain constant. It is natural for systolic blood pressure to rise during the onset of exercise, but diastolic blood pressure values must remain constant. A drop in either during exercise is cause for great concern and can lead to serious cardiovascular damage. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels leading to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to a vascular catastrophe.

Based on the available research, this author strongly recommends that athletes avoid nitric oxide and hemodilator supplements in the interest of safety. Moreover, it has been suggested that these supplements have little or no anabolic or ergogenic benefits for the athlete."



I copied this from another forum, and I just wnated to bring it up. There was a thread on N.O. a while back, and i think it was LBJ who made a great point- basically that us weightlifters should judge for ourselves about the validity of N.O., not these scrawny doctors lol (apologies if that wasn't LBJ or if my memory failed me with the message).

Bottom line is that i'm the type of guy who watches what he puts in his body, and although i love the free samples of both products mentioned above, it looks like it's not worth the risk. Same thing with Nitrix. I just wanted to show you guys this, make of it what you will, and always be safe.

And, to go on record...I believe these products like superpump and no-xplode do increase energy, focus, and vascualuarity.....but they don't "work" in terms of adding size and creatine absorptino etc etc safely or effieciently [imo]


Lastly- a lot of the stuff said in that article goes hand in hand with what BSN says. I called them up, and they admitted the lightheadness, drop in blood pressure etc. but they fail to tell you why and what's being effected. A bit sketchy...

[sorry for the double post in the supplements section]
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Old 05-15-2007, 09:22 PM   #2
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isnt this like the 4th post with the exact same lit? in the past month alone... just like any other product and lifting style. different things work better for different people.
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Old 05-15-2007, 09:43 PM   #3
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Quote:
Originally Posted by wrestlingstalion View Post
isnt this like the 4th post with the exact same lit? in the past month alone... just like any other product and lifting style. different things work better for different people.
this isn't debating the effectiveness of n.o. like the other posts, it's debating the safety. and if it's a "repost" type of thread, i apologize, haven't been on the forum too much in the last few weeks. still thikn it warranted a post.
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Old 05-15-2007, 10:48 PM   #4
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Quote:
Originally Posted by heydespo5269 View Post

I copied this from another forum, and I just wnated to bring it up. There was a thread on N.O. a while back, and i think it was LBJ who made a great point- basically that us weightlifters should judge for ourselves about the validity of N.O., not these scrawny doctors lol (apologies if that wasn't LBJ or if my memory failed me with the message).


[sorry for the double post in the supplements section]
yea it was me bro
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Old 05-16-2007, 06:56 PM   #5
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Despo,

I'm inclined to agree with you and - as you know - I generally frown upon the 'hype product' and the pimps that push them. For the sake of argument, however, the studies listed in the article are kind of ancient history in terms of sports supplementation I would think

Have anyone seen anything more current? Perhaps that supports or contradicts these views?

I ask because I found a bottle of NO as well as a bottle of volumizer in my stash, both of which will expire this year. I had planned to use them up as opposed to just tossing them, but triglycerides & BP are two things that I keep a pretty close eye on.
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Old 05-16-2007, 07:00 PM   #6
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^ it's just so frustrating that their is no reliable source, imo, of where to get info on these products. you know if u call bsn or anyone like that their not going to tell you the real deal. we need to find a doctor on this forum lol.
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Old 07-16-2007, 05:26 PM   #7
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Interesting post. It does make sense in a way that N.O. can just be a bunch of bs from what that article stats.
It seems like it's working wonders on me though.
Ever since I bought BSN's Mass Stack a month in a half ago i've put on 8 or 9 pounds of muscle.
But I do understand, everyone should definately watch what they gulp down every day before they hit the iron.
 
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ALL THIS HYPED STUFF IS GARBAGE
Old 07-16-2007, 06:01 PM   #8
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if any of this shit worked everybody would look like me..lol...
 
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Old 07-16-2007, 06:45 PM   #9
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i dont like it personally.
 
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Old 07-16-2007, 10:08 PM   #10
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NO works for me. end of story
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